Metastatic Renal Cell Carcinoma

Solitary nodule on the temple of an 80 year old man, excised to rule out basal cell carcinoma.  The tumor cells have clear cytoplasm with nuclear pleomorphism, some nucleoli, and increased mitotic activity.  There is also prominent vascularity.  Further review of the clinical history revealed that the patient underwent nephrectomy for clear cell renal cell carcinoma 2 years previously.  I thought this lesion showed changes similar to a perivascular epithelial cell tumor or PEComa.

Related articles are included in the links below:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929522/?tool=pubmed

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1578574/?tool=pubmed

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